Zhuo Chu - Academic CV

Education

Master's Candidate - Biotechnology Science (Bioinformatics)

2022.09 - 2024.06

Kean University · GPA: 3.381/4.0

Thesis: Exploring the Anti-Aging Potential of Metabolite M47: Mechanistic Insights and Therapeutic Prospects in a Tert-Butyl Hydroperoxide-Induced Human Cell Model

Advisor: Professor Siew Woh Choo

Undergraduate - Bioengineering

2017.09 - 2021.06

Jilin Agricultural University · GPA: 3.51/5.0

Thesis: Prokaryotic Expression and Characterization of Recombinant Canine FGF21 Protein

Advisor: Prof. Lili Guan

Research Experience

Bioinformatic Evaluation of CD4+ T Cell Gene Expression in DJ-1 Knockout Mice: Implications for Athletic Health and Performance

2023 - 2024

Research Team Member · Collaborators: Wang Zhenghao, Xie Yibin, Zhao Chenyan

Analyzed T cell functional alterations in DJ-1 knockout mice using GSE173904 dataset
Identified critical roles of calcium signaling and cAMP signaling pathways
Collaborative project with Hong Kong University of Science and Technology, manuscript accepted by Revista multidisciplinar de las Ciencias del Deporte (Co-author)

Exploring the Anti-Aging Potential of Metabolite M47: Mechanistic Insights and Therapeutic Prospects in a Tert-Butyl Hydroperoxide-Induced Human Cell Model

2022 - 2024

Lead Researcher · Advisor: Professor Siew Woh Choo

Conducted RNA sequencing analysis of TBHP-induced HaCaT cell gene expression changes
Identified key pathways including enhanced mitochondrial function and increased ribosome biogenesis
Master's thesis research project

Prokaryotic Expression of Recombinant Canine FGF21 Protein

2019 - 2021

Lead Researcher · Advisor: Prof. Lili Guan

Successfully constructed pET-28a-SUMO-dFGF21 expression vector and obtained properly folded recombinant dFGF21 protein
Third Prize in 3rd National Life Science Competition for College Students, Undergraduate thesis project

Functional Study of CtDHN1 Gene in Carthamus tinctorius L.

2018 - 2020

Research Assistant · Advisor: Prof. Lili Guan

Participated in molecular cloning and plant tissue culture
Co-authored paper published in Chinese Journal of Oil Crop Sciences

Publications

[1] Wang, Z., Xie, Y., Chu, Z., & Zhao, C.
2024

Bioinformatic Evaluation of CD4+ T Cell Gene Expression in DJ-1 Knockout Mice: Implications for Athletic Health and Performance.

Revista multidisciplinar de las Ciencias del Deporte (Accepted)
[2] Dong, C., Yang, J., Liu, Z., Li, H., Chu, Z., Wen, Q., Xie, Z., Liu, S., Guan, L.
2020

Cloning and Functional Analysis of CtDHN1 Gene Associated with Abiotic Stress in Carthamus tinctorius L. [J].

Chinese Journal of Oil Crop Sciences, 42(1):85. DOI

Awards & Honors

Full Scholarship, Kean University

2022-2024

Multiple Academic Scholarships, Jilin Agricultural University

2018-2021

Third Prize, 4th National Life Science Innovation Competition

Jul 2019

Third Prize, 3rd National Life Science Competition

May 2019

Second Prize, 3rd National Life Science Innovation Competition

Aug 2018

Technical Skills

Experimental Techniques

Molecular cloning, Western Blot, qPCR
Plant/animal cell culture, immunofluorescence staining
Bioinformatics analysis (Python/R)

Language Proficiency

TOEFL iBT: 101 (2022)
2 years of full English instruction (Kean University)

Professional Experience

Changchun Xiyuhong Biotechnology Co., Ltd.

Dec 2020 - Present

Shareholder/Supervisor/R&D Technician

Corporate management and financial oversight
New product development

Prof. Siew Woh Choo Research Group

Sep 2022 - Jun 2024

Research Assistant

Assisted in experimental project execution
Data collection and analysis